Process for the manufacture of 2-hydroxy-3-bromo-5-pyridin arsonic acid



Patented 14, 1928.

ADTHUB ZBINZ AND CUB'I. 31TH, BERLIN, GERMANY.

PROCESS FOR THE MANUFACTURE OF Q-HYDROXY-S-BROMO-S-PYRIDIN ARSONIC ACID.

No Drawing. Application filed December 17 According to our invention the 2-hydroxy- 3-bromo-5-pyridin arsonic acid is obtained by reacting elementary bromine or such substances as are able to supply the same upon 2-hydroxy-5-pyridin arsonic acid. If for instance bromine is allowed to react upon a solution of the starting material in suit able solvents such as water or the like it is possible to replace the hydrogen atom in 3- positionby bromine without any difliculty whatever. This result could not be expected because it is known that it is im essible to introduce iodine into the 2-hy roxy-5- pyridin arsonic acid in the same manner, in this case 2-hydroxy-3-5-di-iodo-fpyridin being produced with elimination o the arsonic group.

Example:

no no no no at 0 0 +nnr.

on on 2-hydroxy-pyridin-5-arsonic acid 11 ms. are (fi -solved in 50 cc. glacial acetic acid shape of 1920, Serial n6. 155,530, and in Germany December 21. ms.

adding 75 cc. water and heating the mixture. To Ctlhisnsoldutionb3 3c. of blilwimine are addid ra ua T0 T0 w ist a itatin t e olutiom Aft r I}; has b g for some time the solution is evaporated to one third of its original volume. On cooling the mixture the new substance is deposited in crystals. It is obtained in the small white needles on crystallization from alcohol. The h droxy-bromopyridin arsonic acid thus obtained has strong t panocidal and spirillocidal properties. e substance is intended for therapeutical use and also to serve as starting material for the production of other new substances.-

What we claim is: T 1. Process for the manufacture of 2- hidroxy-3-bromo-5-pyridin arsonic acid w ich consists in reacting bromine upon 2- hydroxy-5-pyridin arsonic acid.

Signed at Berlin in the county of Brandenburg and State of Prussia this th day of November A. D. 1926.

ARTHUR BINZ. cum" BATH.

een allowed to stand 

